The coronavirus (COVID 19) pandemic is one of the most terrifying disasters of the 21st century. The non-pharmaceutical interventions (NPIs) implemented to control the spread of the disease had numerous positive consequences. However, there were also unintended consequences—positively or negatively related to the nature of the interventions, the target, the level and duration of implementation. This article describes the unintended economic, psychosocial and environmental consequences of NPIs in four African countries.